期刊
FITOTERAPIA
卷 82, 期 3, 页码 508-511出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2011.01.004
关键词
Vladimiria souliei; Sesquiterpene; Inhibitory effects of nitric oxide production
资金
- Fundamental Research Funds for the Central Universities, China
- Natural Science Foundation of Tianjin, China [09JCZDJC22000]
As a part of our ongoing search for plant-derived compounds that inhibit nitric oxide production, the methanol extract of the roots of Vladimiria souliei was found to show significant inhibitory effects on INF-gamma-induced nitric oxide production in murine macrophage RAW264.7 cells. Bioactivity-guided isolation of the extract yielded two most active sesquiterpenes, including a new compound, named souliene A (1) and alismol (2). Their structures were elucidated by spectroscopic methods (IR, ESIMS, HRESIMS, 1D and 2D NMR). Two isolates showed promising inhibitory effects on INF-gamma-induced nitric oxide production in murine macrophage RAW264.7 cells. (C) 2011 Elsevier B.V. All rights reserved.
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