期刊
FITOTERAPIA
卷 82, 期 4, 页码 528-533出版社
ELSEVIER
DOI: 10.1016/j.fitote.2010.12.003
关键词
Vitex agnus-castus; Labdane diterpene; Viteagnusin I; Flavonoids; Opioid activity
资金
- National Center for Complementary and Alternative Medicine (NCCAM) [P50 AT000155]
- Office of Dietary Supplements (ODS)
- National Institute of General Medical Sciences (NIGMS)
- Office for Research on Women's Institutes of Health (ORWH)
A new labdane-diterpene, viteagnusin I (1), together with 23 known phytoconstituents were isolated from the fruits of Vitex agnus-castus L, and their structures characterized by spectroscopic methods (NMR and MS). The known compounds include ten flavonoids, five terpenoids, three neolignans, and four phenolic compounds, as well as one glyceride. Biological evaluation identified apigenin, 3-methylkaempferol, luteolin, and casticin as weak ligands of delta and mu opioid receptors, exhibiting dose-dependent receptor binding. (C) 2011 Elsevier B.V. All rights reserved.
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