期刊
FITOTERAPIA
卷 82, 期 7, 页码 939-949出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2011.05.009
关键词
lsoflavone; Flavanone; Estrogenicity; Postmenopause; Hot flushes; Antiatherogenic
资金
- Alexander von Humboldt Foundation at the University of Technology in Dresden
To determine whether the two major compounds of Erythrina lysistemon are active principles accounting for Erythrina estrogenic effects, we used a postmenopause-like model of ovariectomized Wistar rats to evaluate their effects on some menopausal problems. Ovariectomized rats were orally treated either with compound 1 or compound 2 at 1 and 10 mg/kg BW for 28 days. Estradiol valerate served as the reference substance. As results, compounds 1 and 2 displayed estrogen-like effects on the uterus and the vagina, and reduced atherogenic risks by decreasing the two assessed atherogenic parameters, the total cholesterol/HDL-cholesterol ratio and the atherogenic index of plasma. (C) 2011 Elsevier B.V. All rights reserved.
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