期刊
FITOTERAPIA
卷 82, 期 2, 页码 168-172出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2010.08.014
关键词
Microtea debilis; 5-O-beta-D-Glucopyranosyl cirsimaritin; 5, 4 '-O-beta-D-Diglucopyranosyl cirsimaritin; Human cancer cell lines (Hen G2, COLO 205, HL-60); Anti-inflammatory
资金
- Naturex, Inc.
Two new 5-O-glucosylflavones, 5-O-beta-D-glucopyranosyl cirsimaritin (1) and 5, 4'-O-beta-D-diglucopyranosyl cirsimaritin (2), four known flavonoids, cirsimarin (3), cirsimaritin (4), salvigenin (5), 4', 5-dihydroxy-7-methoxyflavone (6), and a norisoprenoid, vomifoliol (7), have been isolated from the aerial parts of Microtea debilis. All isolates were tested for cytotoxicity in human cancer cell lines (Hep G2, COLO 205, and HL-60) and anti-inflammatory activities in LPS-treated RAW264.7 macrophages. Compound 6 was found to be a potent inhibitor to nitrite production in macrophages. Compounds 2, 4, 6, and 7 showed moderate anti-proliferative activity against COLO-205 cells with IC50 values of 7.1, 13.1, 6.1, and 6.8 mu M, respectively. (C) 2010 Elsevier B.V. All rights reserved.
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