期刊
FITOTERAPIA
卷 81, 期 7, 页码 816-819出版社
ELSEVIER
DOI: 10.1016/j.fitote.2010.04.009
关键词
Cannabis sativa L.; Phytocannabinoids; Anti-inflammatory activity; Croton oil assay; Cannabinoids; Cannabivarins
A selection of seven phytocannabinoids representative of the major structural types of classic cannabinoids and their corresponding cannabivarins was investigated for in vivo topical anti-inflammatory activity in the Croton oil mouse ear dermatitis assay. Differences in the terpenoid moiety were far more important for anti-inflammatory activity than those at the C-3 alkyl residue, suggesting the involvement not only of cannabinoid receptors, but also of other inflammatory end-points targeted by phytocannabinoids. (C) 2010 Elsevier B.V. All rights reserved.
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