期刊
FITOTERAPIA
卷 81, 期 6, 页码 569-576出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2010.01.019
关键词
Estradiol valerate; Pueraria mirifica; Puerarin; Uterus; Uterine gland; Vagina
资金
- Faculty of Science and Primate Research Unit, Chulalongkorn University, Thailand
A weak estrogenicity of puerarin on reproductive organs was addressed in female rats. In short-term treatment, immature ovariectomized rats were injected with 0.7 mg/kg BW/day of puerarin, for 14 days. Puerarin did not increase uterus weights, endometrium and myometrium areas, and the percent of cornified cells (%Co), but it increased the number of uterine glands. In long-term treatment, mature rats were injected with 7.0 mg/kg BW/day of puerarin for 140 days. Puerarin did not increase uterus weights, endometrium and myometrium areas, and the number of uterine glands, but a significant increase in the %Co was observed from day 98 onwards. (C) 2010 Elsevier B.V. All rights reserved.
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