期刊
FITOTERAPIA
卷 81, 期 8, 页码 1117-1124出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2010.07.009
关键词
Potentilla anserina polysaccharide; Immunosuppression; Immunomodulatory effect
资金
- National Natural Science Foundation of China [30371056]
The polysaccharide (PAP) from Potentilla anserina was evaluated for modulating effects by using mouse peritoneal macrophage and the immunosuppressed-model cyclophosphamide-induced. Phagocytotic and mononuclear phagocytic system function assays showed that PAP stimulated the phagocytosis of phagocyte. Splenocyte proliferation assay showed that PAP acted the effect combining Con A or LPS in splenocyte proliferation. The parameters detected showed that PAP increased thymus and spleen indices, the levels of LDH and ACP in the spleen, and IL-10and IFN-gamma in serum in immunosuppressed mice. The results suggest that PAP is involved in immunomodulatory effects leading to the exploration for PAP as a potential immunostimulant. (C) 2010 Elsevier B.V. All rights reserved.
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