期刊
FITOTERAPIA
卷 81, 期 2, 页码 124-131出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2009.08.019
关键词
Polygonum sachalinensis; Invasive plant; N-trans-feruloyltyramine; Quercetin-3-O-arabinopyranoside; alpha/beta-glucosidase; Acetylcholinesterase
资金
- Swiss National Science Foundation [200020-107775]
- China Scholarship Council
Polygonum sachalinensis is a widespread invasive plant in Europe. Chemical profiles of its different organs were studied by HPLC-UV-ESI/MS. Seven major constituents quercetin-3-O-beta-D-galactopyranoside, quercetin-3-O-arabinopyranoside, lapathoside D, N-trans-feruloyltyramine, lapathoside C, hydropiperoside, and vanicoside B were isolated and identified. The free radical-scavenging, alpha/beta-glucosidase, and acetylcholinesterase inhibitory activities of crude MeOH extracts and isolated compounds were studied. The structure-activity relationships were discussed. The chemical profiles revealed flavonoids and phenylpropanoids are the major compounds of all the organs of this plant. Quercetin-3-O-arabinopyranoside, lapathoside D, N-trans-feruloyltyramine, lapathoside C and hydropiperoside were isolated from this species for the first time. In the alpha-glucosidase bioassay, quercetin-3-O-beta-D-galactopyranoside, lapathoside D and N-transferuloyltyramine demonstrated stronger activities than the positive reference acarbose. The trend in scavenging power showed no relation to enzyme inhibition in the test models. (C) 2009 Elsevier B.V. All rights reserved.
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