期刊
FITOTERAPIA
卷 81, 期 2, 页码 145-148出版社
ELSEVIER
DOI: 10.1016/j.fitote.2009.08.010
关键词
Dysoxylum binectariferum; Rohitukine; Anticancer activity; Flavopiridol
资金
- Department of Biotechnology, Government of India
Rohitukine, a chromane alkaloid, is a precursor of flavopiridol, a promising anti-cancer compound. Currently in Phase III clinical trials, flavopiridol is a potent inhibitor of several cyclin-dependent kinases (CDKs). Rohitukine was first reported from Amoora rohituka (0.083% dry weight) followed by that in Dysoxylum binectariferum (0.9% dry weight), both belonging to the family Meliaceae. Here, we report incredibly high yields of rohitukine (7% dry weight) in trees of D. binectariferum from the Western Ghats, India. Crude extracts of the tree were found to be highly effective against ovarian and breast cancer lines tested. (C) 2009 Elsevier B.V. All rights reserved.
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