期刊
FITOTERAPIA
卷 80, 期 1, 页码 73-76出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2008.10.003
关键词
Orostachys japonicus; Crassulaceae; mu-Calpain; (-)-Epicatechin 5-gallate
资金
- Korean Ministry of Commerce, Industry and Energy [10027898-2007-22]
- Ministry of Education & Human Resources Development, Korea
Calpains are calcium-dependent proteases that cleave a variety of intracellular substrates. The overactivation of mu-calpain is associated with a wide range of disease conditions. To search for calpain inhibitors from natural products, the phytochemical constituents of the ethyl acetate fraction of the whole plant of Orostachys japonicus (Crassulaceae) were studied. The various chromatographic separation of this fraction led to the isolation of a new tannin, (-)-epicatechin 5-gallate (1) along with 9 known compounds. Their structures were elucidated by spectroscopic and chemical analyses. Among them, (-)-epicatechin 5-gallate (1) and kaempferol (9) exhibited moderate inhibitory activity against mu-calpain with IC50 values of 18.0 +/- 2.9 and 15.4 +/- 2.0 mu g/ml, respectively. (C) 2008 Elsevier B.V. All rights reserved.
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