期刊
FITOTERAPIA
卷 80, 期 5, 页码 270-273出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2009.03.003
关键词
Parmotrema saccatilobum; Lichen; Atranorin; Chloroatranorin; COX inhibition
资金
- NIH [ICBG 5UO1TW006671, RR14768, RR06262]
A traditional preparation of Parmotrema saccatilobum (Taylor) Hale (Family: Parmeliaceae) is being considered for inclusion into the PNG national drug formulary by the Ministry of Health Taskforce on Traditional Medicines. The lichen preparation is traditionally used in the Milne Bay province of Papua New Guinea for analgesic and anti-inflammatory activities. A hexane extract of P. saccatilobum yielded the principle components atranorin and chloroatranorin. Atranorin and chloroatranorin were tested in a COX-1 and -2 enzyme inhibition assay, which showed that atranorin inhibited COX-1 in a dose dependent manner and suggests partial inhibition by atranorin and chloroatranorin of COX-2 and COX-1, respectively. (C) 2009 Elsevier B.V. All rights reserved.
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