期刊
FITOTERAPIA
卷 80, 期 2, 页码 138-142出版社
ELSEVIER
DOI: 10.1016/j.fitote.2009.01.001
关键词
Chlorogenic acid; Polyphenols; Ilex paraguariensis; Myeloperoxidase; Chlorination; Chlorotyrosine
资金
- Touro University-California
- FAPESP, Sao Paulo, Brazil
We hypothesized that chlorogenic acids, the main phenolics in coffee, many fruits and Ilex paraguariensis extracts, protect paraoxonase 1 activity in HDL from inactivation by chlorination at concentrations of HOCl (50 mu M) and chlorogenic acid (2-10 mu M) compatible with those found in humans. When human HDL was incubated in the presence of HOCl/OCl-, a concentration dependent loss of activity was apparent. Of interest, 5 caffeoylquinic acid at 5 mu mol/L affords more than 60% protection of the activity reaching 100% at 25 mu mol/L. This compound and the plant sources that are rich in them may be protectors of paraoxonase 1 activity. (C) 2009 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据