期刊
FISHERIES SCIENCE
卷 77, 期 3, 页码 375-384出版社
SPRINGER JAPAN KK
DOI: 10.1007/s12562-011-0341-z
关键词
Rhubarb; Aeromonas hydrophila; UPLC; Antimicrobial property
类别
资金
- Key Open Laboratory for Genetic Breeding of Aquatic Animals and Aquaculture Biology, Ministry of Agriculture [BZ2009-24]
- earmarked fund for Modern Agro-industry Technology Research System, China [nycytx-49]
Antibacterial properties of crude extract from rhubarb and its major bioactive compounds against Aeromonas hydrophila were assayed. Major bioactive compounds (anthraquinone derivatives) in rhubarb collected from different cultivation areas were determined by ultra-performance liquid chromatography (UPLC); the antibacterial activity [minimum inhibitory concentration (MIC)] of rhubarb was positively related to the anthraquinone content (r = 0.9306, P < 0.01). The MIC values of five anthraquinones against A. hydrophila were found to be in the range 50-200 mu g/ml. Action-mode studies showed that anthraquinones (emodin) inhibits cellular functions by binding to cell DNA after penetrating the cell membrane, resulting in cell death. The present study suggests that anthraquinones extracted from rhubarb have potential use as antimicrobials for control of A. hydrophila.
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