期刊
FISH & SHELLFISH IMMUNOLOGY
卷 35, 期 6, 页码 1729-1739出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fsi.2013.09.032
关键词
Teleost; Mucosa; Immune system; Commensal; Pathogen
资金
- National Science Foundation [NSF-MCB-0719599]
- National Institutes of Health [R01GM085207-01]
- CETI COBRE grant [P20GM103452]
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [1022300] Funding Source: National Science Foundation
The field of mucosal immunology research has grown fast over the past few years, and our understanding on how mucosal surfaces respond to complex antigenic cocktails is expanding tremendously. With the advent of new molecular sequencing techniques, it is easier to understand how the immune system of vertebrates is, to a great extent, orchestrated by the complex microbial communities that live in symbiosis with their hosts. The commensal microbiota is now seen as the extended self by many scientists. Similarly, fish immunologist are devoting important research efforts to the field of mucosal immunity and commensals. Recent breakthroughs on our understanding of mucosal immune responses in teleost fish open up the potential of teleosts as animal research models for the study of human mucosal diseases. Additionally, this new knowledge places immunologists in a better position to specifically target the fish mucosal immune system while rationally designing mucosal vaccines and other immunotherapies. In this review, an updated view on how teleost skin, gills and gut immune cells and molecules, function in response to pathogens and commensals is provided. Finally, some of the future avenues that the field of fish mucosal immunity may follow in the next years are highlighted. (C) 2013 Elsevier Ltd. All rights reserved.
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