期刊
FISH & SHELLFISH IMMUNOLOGY
卷 29, 期 5, 页码 773-777出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fsi.2010.07.002
关键词
Zebrafish; Maternal immunity; Lysozyme; Complement; Cooperation
资金
- Natural Science Foundation of Shaanxi Province [2010JQ3010]
- WeinanTeachers University [10ykz008]
Most fish embryos develop in an aquatic environment full of potential pathogens. How fish embryos survive pathogenic attacks before the maturation of their own immunocompetence remains poorly understood. Here we demonstrated that bacteriolytic mechanism contributed to the antibacterial activity of zebrafish egg cytosol. In addition, the maternal lysozyme in the egg cytosol plays a key role in the bacteriolytic activity of the zebrafish eggs, which can be significantly stimulated by the cooperation with complement. This is the first report providing the evidence for the functional role of the maternal lysozyme and its cooperation with complement in fish eggs. (C) 2010 Elsevier Ltd. All rights reserved.
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