期刊
JOURNAL OF THE NEUROLOGICAL SCIENCES
卷 355, 期 1-2, 页码 72-74出版社
ELSEVIER
DOI: 10.1016/j.jns.2015.05.020
关键词
Parkinson's disease; FGF20; Polymorphism; Iranian population; 3 ' UTR; miRNA-433
资金
- Shahid Beheshti University of Medical Sciences [1391-1-91-8902]
DNA variations in the fibroblast growth factor 20 gene have been reported to be associated with Parkinson's disease (PD). The rs12720208, a functional SNP located in the 3'UTR region of the gene, was reported as a risk factor for PD. A number of studies, which tried to replicate the result in different populations, failed to detect any associations. In this study, we genotyped rs2720208 SNP in 520 PD patients and 520 healthy controls both from Iran. Significant differences were found in allele and genotype frequencies between patients and controls (p < 0.0001 for both). Our results suggest that the rs12720208 polymorphism may be a risk factor for PD in Iranian population. (C) 2015 Elsevier B.V. All rights reserved.
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