期刊
ANNALS OF OCCUPATIONAL HYGIENE
卷 60, 期 3, 页码 318-333出版社
OXFORD UNIV PRESS
DOI: 10.1093/annhyg/mev083
关键词
biological exposure equivalent; biological monitoring; biomarkers; exposure assessment; petrol station workers; urinary benzene; urinary MTBE
资金
- Lombardy Region, PPTP project
To assess exposure to benzene (BEN) and other aromatic compounds (toluene, ethylbenzene, m+p-xylene, o-xylene) (BTEX), methyl tert-butyl ether (MTBE), and ethyl tert-butyl ether (ETBE) in petrol station workers using air sampling and biological monitoring and to propose biological equivalents to occupational limit values. Eighty-nine petrol station workers and 90 control subjects were investigated. Personal exposure to airborne BTEX and ethers was assessed during a mid-week shift; urine samples were collected at the beginning of the work week, prior to and at the end of air sampling. Petrol station workers had median airborne exposures to benzene and MTBE of 59 and 408 A mu g m(-3), respectively, with urinary benzene (BEN-U) and MTBE (MTBE-U) of 339 and 780ng l(-1), respectively. Concentrations in petrol station workers were higher than in control subjects. There were significant positive correlations between airborne exposure and the corresponding biological marker, with Pearson's correlation coefficient (r) values of 0.437 and 0.865 for benzene and MTBE, respectively. There was also a strong correlation between airborne benzene and urinary MTBE (r = 0.835). Multiple linear regression analysis showed that the urinary levels of benzene were influenced by personal airborne exposure, urinary creatinine, and tobacco smoking [determination coefficient (R (2)) 0.572], while MTBE-U was influenced only by personal exposure (R (2) = 0.741). BEN-U and MTBE-U are sensitive and specific biomarkers of low occupational exposures. We propose using BEN-U as biomarker of exposure to benzene in nonsmokers and suggest 1457ng l(-1) in end shift urine samples as biological exposure equivalent to the EU occupational limit value of 1 p.p.m.; for both smokers and nonsmokers, MTBE-U may be proposed as a surrogate biomarker of benzene exposure, with a biological exposure equivalent of 22 A mu g l(-1) in end shift samples. For MTBE exposure, we suggest the use of MTBE-U with a biological exposure equivalent of 22 A mu g l(-1) corresponding to the occupational limit value of 50 p.p.m.
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