期刊
FERTILITY AND STERILITY
卷 102, 期 2, 页码 424-434出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2014.05.001
关键词
HIV; insemination; IUI; IVF; serodiscordant
资金
- Gilead
Objective: To assess procreative outcomes for HIV-positive men and women with seronegative partners. Design: Systematic review and meta-analysis. Setting: Not applicable. Patient(s): Twenty-four studies with extractable data for HIV-serodiscordant couples undergoing intrauterine insemination (IUI) or in vitro fertilization (IVF). Intervention(s): None. Main Outcome Measure(s): Primary outcomes: HIV transmission to a seronegative partner and per cycle fecundability; secondary outcomes: analysis of multiple gestation rates, miscarriage rates, and cancellation rates. Result(s): For serodiscordant couples, HIV-positive men or women undergoing IUI and IVF treatment had a 17%, 30%, 14%, and 16% per cycle fecundability, respectively. Multiple gestation rates were 10%, 33%, 14%, and 29%, respectively. Miscarriage rates were 19%, 25%, 13%, and 20%, respectively. No HIV transmission was observed in 8,212 IUI and 1,254 IVF cycles, resulting in 95% confidence that the true rate is 4.5 transmissions per 10,000 IUI cycles or less. Conclusion(s): In serodiscordant couples, IUI and IVF seem effective and safe based on the literature. Evidence-based practice and social justice suggest that our field should increase access to care for HIV-serodiscordant couples. ((C)2014 by American Society for Reproductive Medicine.)
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