Serum bisphenol-A concentration and sex hormone levels in men

Objective: To evaluate the association between serum bisphenol-A (BPA) concentration and sex hormone levels in men. Design: Cross-sectional study. Setting: Not applicable. Patient(s): A total of 290 men with or without BPA exposure in the workplace. Intervention(s): None. Main Outcome Measure(s): Serum sex hormone levels. Result(s): After adjustment for potential confounders using linear regression, increasing serum BPA concentration was statistically significantly associated with [1] decreased androstenedione levels, [2] decreased free testosterone levels, [3] decreased free androgen index, and [4] increased sex hormone-binding globulin levels. Comparison of hormone levels between workers exposed and unexposed to BPA showed similar associations. Conclusion(s): Exposure to a high BPA level may impact sex hormone levels in men. (C) 2013 by American Society for Reproductive Medicine.