期刊
FERTILITY AND STERILITY
卷 99, 期 4, 页码 1049-1053出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2012.11.007
关键词
Quantitative real-time PCR; comprehensive chromosome screening; embryo selection; aneuploidy screening; preimplantation genetic diagnosis
资金
- Ferring Pharmaceuticals
- EMD Serono
Embryonic comprehensive chromosomal euploidy may represent a powerful biomarker to improve the success of IVF. However, there are a number of aneuploidy screening strategies to consider, including different technologic platforms with which to interrogate the embryonic DNA, and different embryonic developmental stages from which DNA can be analyzed. Although there are advantages and disadvantages associated with each strategy, a series of experiments producing evidence of accuracy, safety, clinical predictive value, and clinical efficacy indicate that trophectoderm biopsy and quantitative real-time polymerase chain reaction (qPCR)-based comprehensive chromosome screening (CCS) may represent a useful strategy to improve the success of IVF. This Biomarkers in Reproductive Medicine special issue review summarizes the accumulated experience with the development and clinical application of a 4-hour blastocyst qPCR-based CCS technology. (Fertil Steril (R) 2013;99:1049-53. (C) 2013 by American Society for Reproductive Medicine.)
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