4.7 Article

Aromatase inhibitor treatment limits progression of peritoneal endometriosis in baboons

期刊

FERTILITY AND STERILITY
卷 99, 期 3, 页码 656-+

出版社

ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2012.11.021

关键词

Endometriosis; aromatase inhibitors; baboon model; laparoscopy

资金

  1. Eunice Kennedy Shriver National Institute of Child Health and Human Development/National Institutes of Health, Specialized Cooperative Centers Program in Reproduction and Infertility Research [U54 HD 40093]
  2. National Institutes of Health [TW 01339, K12HD050121]

向作者/读者索取更多资源

Objective: To determine the effect of inhibiting aromatase activity on endometrial lesion growth and aromatase expression in a baboon model of induced endometriosis. Design: Prospective study. Setting: Primate research institute. Animal(s): Sixteen olive baboons. Intervention(s): Sixteen olive baboons with induced endometriosis were examined with laparoscopy 10 months after disease inoculation. Animals in group 1 (n = 10) were treated with 1.25 mg/d of the aromatase inhibitor (AI) letrozole, and animals in group 2 (n = 6) were given a placebo for a total of 6 months. Main Outcome Measure(s): Total number of endometriotic lesions, morphology, and volume of lesions, as well as semiquantitative reverse transcription-polymerase chain reaction and quantitative polymerase chain reaction for levels of aromatase cytochrome messenger RNA were measured. Ovarian volumes were evaluated before treatment initiation and every 2 months during the study. Result(s): Treatment of group 1 animals with an AI significantly decreased lesion volume from baseline measurements, whereas the placebo-treated animals showed an increase in lesion volume. Aromatase messenger RNA levels in lesions in the AI-treated animals were significantly lower compared with the placebo-treated animals. Ovarian volumes were significantly increased at 6 months of AI treatment compared with pretreatment volumes. Conclusion(s): These findings suggest that suppression of aromatase cytochrome P450 may inhibit the in vivo growth of endometriotic lesions in baboons. (Fertil Steril (R) 2013;99:656-62. (C) 2013 by American Society for Reproductive Medicine.)

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