期刊
FERTILITY AND STERILITY
卷 99, 期 4, 页码 998-1007出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2013.01.111
关键词
Male infertility; proteomics; genomics; biomarker
资金
- Male Reproductive Health Research (MRHR) Career Development Physician-Scientist Award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Program [K12, HD073917-01]
- AUA Foundation Russell Scott Jr., M.D., Resident Research Award
- National Institutes of Health from the Eunice Kennedy Shriver NICHD [P01HD36289]
- National Institutes of Health from the National Institute of Kidney and Digestive Diseases [1R01DK078121]
Although male factors account for approximately 50% of all infertility, the mechanisms underlying their origin are unknown. Currently, clinicians rely primarily on semen analyses to predict male reproductive potential and chart treatment success. Even when invasive procedures are performed, the causes of male factor infertility frequently remain elusive. Recently, the advent of new technologies has spurred the search for novel male infertility biomarkers, and the detection of genes, proteins, or metabolites unique to the infertile male holds much promise. The concept that a cost-effective, noninvasive, and accurate set of biomarkers can be identified to diagnose male factor infertility is tantalizing. This review focuses on the various methodologies used in the discovery of novel biomarkers along with their findings. Specific attention is paid to recent advances in the fields of genetics, proteomics, and metabolomics. (Fertil Steril (R) 2013;99:998-1007. (c) 2013 by American Society for Reproductive Medicine.)
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