期刊
FERTILITY AND STERILITY
卷 98, 期 1, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2012.03.029
关键词
Vitamin D; antimullerian hormone; mullerian-inhibiting substance; HIV; ovarian reserve; insulin resistance; obesity
资金
- National Institutes of Health (NIH)
- Merck
- National Institute of Allergy and Infectious Diseases [UO1-AI-35004, UO1-AI-31834, UO1-AI-34994, UO1-AI-34989, UO1-AI-34993, UO1-AI-42590]
- Eunice Kennedy Shriver National Institute of Child Health and Human Development [UO1-HD-32632]
- National Cancer Institute
- National Institute on Drug Abuse
- National Institute on Deafness and Other Communication Disorders
- National Center for Research Resources (University of California, San Francisco-Clinical and Translational Science Institute) [UL1 RR024131]
Objective: To study the correlation between circulating 25-hydroxyvitamin D (25OH-D) levels and serum antimullerian hormone (AMH) in women enrolled in the Women's Interagency HIV Study. Design: Cross-sectional study. Setting: None. Patient(s): All premenopausal women (n = 388) with regular menstrual cycles were included and subdivided into three groups: group 1 with age <35 years (n = 128), group 2 with age 35-39 years (n = 119), and group 3 with age >= 40 years (n = 141). Intervention(s): Serum for 25OH-D, AMH, fasting glucose and insulin, and creatinine levels. Main Outcome Measure(s): Correlation between 25OH-D and AMH before and after adjusting for HIV status, body mass index, race, smoking, illicit drug use, glucose and insulin levels, estimated glomerular filtration rate, and geographic site of participation. Result(s): After adjusting for all covariates, the regression slope in all participants for total 25OH-D predicting log(10)AMH for 25-year-olds (youngest participant) was -0.001 (SE = 0.008); and for 45-year-olds (oldest participant) the corresponding slope was +0.011 (SE = 0.005). Fasting insulin level was negatively correlated with serum AMH. The regression slope for the correlation between 25OH-D and AMH in group 1 was +0.002 (SE = 0.006); in group 2 was +0.006 (SE = 0.005); and in group 3 was +0.011 (SE = 0.005). There was no association between HIV and AMH. Conclusion(s): A novel relationship is reported between circulating 25OH-D and AMH in women aged >= R40 years, suggesting that 25OH-D deficiency might be associated with lower ovarian reserve in late-reproductive-aged women. (Fertil Steril (R) 2012. (C) 2012 by American Society for Reproductive Medicine.)
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