Mayer-Rokitansky-Kuster-Hauser syndrome: a review of 245 consecutive cases managed by a multidisciplinary approach with vaginal dilators

Objective: To understand the efficacy of vaginal dilators in the management of Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome. Design: Retrospective sequential study. Setting: Hospital. Patient(s): 245 women. Intervention(s): Vaginal dilators. Main Outcome Measure(s): Functional vaginal length and sexual satisfaction. Result(s): Of the patients who completed the program, 232 (94.9%) achieved a successful vaginal length (defined as greater than 6 cm in length and maximum width throughout the vagina and especially at the apex) and sexual function. When the program was completed by all patients, 100% of patients were successful. Conclusion(s): Vaginal dilator therapy is the treatment of first choice for creation of the vagina in MRKH syndrome, and the success rates suggest that surgery is rarely, if ever, required. (Fertil Steril (R) 2012; 97: 686-90. (C) 2012 by American Society for Reproductive Medicine.)