Comparison of oral dydrogestrone with progesterone gel and micronized progesterone for luteal support in 1,373 women undergoing in vitro fertilization: a randomized clinical study

Objective: To compare the efficacy of oral dydrogesterone with that of micronized vaginal P gel and micronized P capsule for luteal supplementation. Design: Prospective, randomized clinical study. Setting: Institute of Reproductive Medicine, Kolkata, India. Patient(s): A total of 1,373 infertile women undergoing IVF participated. Intervention(s): Micronized P gel, P capsule, and oral dydrogesterone were administered for luteal support and compared. Main Outcome Measure(s): Demographic profile and pregnancy and miscarriage rates. Result(s): The overall pregnancy rate and miscarriage rate were comparable among the three groups. Conclusion(s): Oral dydrogesterone seems to be a promising drug for luteal support in woman undergoing IVF. (Fertil Steril (R) 2011; 95: 1961-5. (C)2011 by American Society for Reproductive Medicine.)