期刊
FERTILITY AND STERILITY
卷 96, 期 2, 页码 360-365出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2011.05.087
关键词
Endometriosis; epidemiology; histology; incidence; laparoscopy; magnetic resonance imaging
资金
- Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health [NO1-DK-6-3428, NO1-DK-6-3427, 10001406-02]
Objective: To estimate the incidence of endometriosis in an operative cohort of women seeking clinical care and in a matched population cohort to delineate more fully the scope and magnitude of endometriosis in the context of and beyond clinical care. Design: Matched-exposure cohort design. Setting: Surgical centers in the Salt Lake City, Utah, and San Francisco, California, areas. Patient(s): The operative cohort comprised 495 women undergoing laparoscopy/laparotomy between 2007 and 2009, and the population cohort comprised 131 women from the surgical centers' catchment areas. Intervention(s): None. Main Outcome Measure(s): Incidence of endometriosis by diagnostic method in the operative cohort and by pelvic magnetic resonance imaged (MRI) disease in the population cohort. Result(s): Endometriosis incidence in the operative cohort ranged by two orders of magnitude by diagnostic method: 0.7% for only histology, 7% for only MRI, and 41% for visualized disease. Endometriosis staging was skewed toward minimal (58%) and mild disease (15%). The incidence of MRI-diagnosed endometriosis was 11% in the population cohort. Conclusion(s): Endometriosis incidence is dependent on the diagnostic method and choice of sampling framework. Conservatively, 11% of women have undiagnosed endometriosis at the population level, with implications for the design and interpretation of etiologic research. (Fertil Steril (R) 2011; 96: 360-5. (c) 2011 by American Society for Reproductive Medicine.)
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