期刊
FERTILITY AND STERILITY
卷 96, 期 5, 页码 1083-1086出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2011.08.027
关键词
Male factor; sexual abstinence; sperm DNA fragmentation; sperm quality; sperm chromatin dispersion test
资金
- Ministerio de Ciencia y Tecnologia, Spain (MCYT) [BFU2010-16738]
Objective: To evaluate the relationship between duration of sexual abstinence and sperm selection on sperm DNA fragmentation (SDF). Design: Prospective study based on normozoospermic individuals. Setting: Fertility and IVF unit and university unit for research. Patient(s): Two cohorts of normozoospermic individuals: 21 men (aged 25-35 years) attending a clinic and with clearly adverse female factors; and a group of 12 selected donors (aged 20-25 years). Intervention(s): SDF assessment using the sperm chromatin the dispersion test (Halosperm) in two cohorts of normozoospermic men. Main Outcome Measure(s): SDF assessment after 24 hours of abstinence with recurrent ejaculation (one every 24 hours) using neat sperm samples; and SDF assessment before and after sperm selection with abstinence of 3 hours. Result(s): Lower baseline levels of SDF were observed after shorter periods of abstinence between ejaculations (24 hours and 3 hours) than those recommended. This effect is much more marked after quick repetitive ejaculation (3 hours of abstinence) and sperm selection. Conclusion(s): The present results challenge the role of abstinence in current male infertility treatments and suggest that SDF can be efficiently reduced by a biological practice consisting of short-term recurrent ejaculation coupled with effective sperm selection. (Fertil Steril (R) 2011;96:1083-6. (C) 2011 by American Society for Reproductive Medicine.)
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