期刊
FERTILITY AND STERILITY
卷 95, 期 6, 页码 1922-U76出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2011.02.002
关键词
Childhood cancer survivor; hypothalamic irradiation; pituitary irradiation; alkylating agent; pregnancy
资金
- United States Public Health Service [CA-55727, CA-21765]
- Children's Cancer Research Fund
- American Lebanese Syrian Associated Charities (ALSAC)
Objective: To evaluate the effect of hypothalamic/pituitary radiation (HPT RT) dose on the occurrence of first pregnancy. Design: Retrospective cohort study of childhood cancer 5-year survivors (CCS) diagnosed between 1970 and 1986 before 21 years of age at one of 26 North American pediatric cancer treatment centers. Setting: Self-administered questionnaire. Patient(s): A total of 3,619 female CCS who participated in the Childhood Cancer Survivor Study and received no or scatter (<= 0.1 Gy) radiation to the ovaries and 2,081 female siblings (Sibs) of the participants. Intervention(s): None. Main Outcome Measure(s): Self-reported pregnancy events. Result(s): As a group, CCS were as likely to report being pregnant as Sibs (hazard ratio 1.07, 95% confidence interval 0.97-1.19). Multivariable models showed a significant decrease in the risk of pregnancy with HPT RT doses >= 22 Gy compared with those CCS receiving no HPT RT. Conclusion(s): These results support the hypothesis that exposures of 22-27 Gy HPT RT may be a contributing factor to infertility among female CCS. (Fertil Steril (R) 2011; 95: 1922-7. (C)2011 by American Society for Reproductive Medicine.)
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