期刊
FERTILITY AND STERILITY
卷 96, 期 6, 页码 1451-1456出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2011.09.039
关键词
Chronic endometritis; endometrial pathology; infertility; IVF; ICSI; plasma cell
资金
- Andromed
- Ardana
- Ferring
- Genovum
- Glycotope
- Merck Serono
- Organon
- Pantharei Bioscience
- Philips
- PregLem
- Schering
- Schering Plough
- Serono
- Wyeth
- Anecova
- Besins
- Schering-Plough
Objective: To assess the prevalence of chronic endometritis and the impact on the fertility of asymptomatic patients indicated for in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatment. Design: In the context of a randomized controlled trial, a hysteroscopy-guided endometrial biopsy was obtained and histologically examined. The live birth rate (including spontaneous pregnancies) after initiation of IVF/ICSI treatment of patients diagnosed with chronic endometritis was compared with the live birth rate of a randomly selected matched control group of patients without endometritis. Setting: Two tertiary infertility care units. Patient(s): A total of 678 asymptomatic infertile women with a normal transvaginal ultrasound (TVS) who underwent diagnostic hysteroscopy before a first IVF/ICSI treatment cycle. Intervention(s): Hysteroscopy guided endometrial biopsy. Main outcome measure(s): The prevalence of chronic endometritis and the live birth rate (including spontaneous pregnancies) within 3 years after initiation of the randomized controlled trial. Result(s): The prevalence of chronic endometritis in the 606 patients with an adequate biopsy was 2.8%. The cumulative live birth rate (including spontaneous pregnancies) did not significantly differ between patients with or without endometritis: 76% versus 54%. Also, the clinical pregnancy rate per embryo transfer was not significantly different (hazard ratio 1.456, 95% confidence interval 0.770-2.750). Conclusion(s): Chronic endometritis can be rarely diagnosed in a population of asymptomatic infertile patients with a normal TVS before a first IVF/ICSI treatment. Moreover, the reproductive outcome after initiation of IVF/ICSI was not found to be negatively affected by chronic endometritis. In conclusion, the clinical implication of chronic endometritis seems minimal. (Fertil Steril (R) 2011; 96: 1451-6. (C) 2011 by American Society for Reproductive Medicine.)
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