期刊
FERTILITY AND STERILITY
卷 95, 期 8, 页码 2669-2672出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2011.01.168
关键词
Genetics; oocyte quality; sequence variation; zona anomaly; zona pellucida
资金
- Academy of Finland [111274]
- Finnish Cultural Foundation
- Oulu University Hospital
- Oulu University Scholarship Foundation
- Sigrid Juselius Foundation
- Academy of Finland (AKA) [111274, 111274] Funding Source: Academy of Finland (AKA)
To examine putative associations between zona pellucida (ZP) anomalies and sequence variations in genes expressing structural ZP glycoprotein components, sequence data of 31 volunteers participating in IVF treatments were obtained and analyzed together with morphologic data of the respective oocytes. Our results suggest that some of the most frequent zona anomalies may be at least partly explained by sequence variations in genes expressing the four human ZP proteins, especially those in ZP2 and ZP3. (Fertil Steril (R) 2011;95:2669-72. (C) 2011 by American Society for Reproductive Medicine.)
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