Can intracytoplasmic morphologically selected sperm injection be used to select normal-sized sperm heads in infertile patients with macrocephalic sperm head syndrome?

Objective: To study the chromosomal content of spermatozoa selected by intracytoplasmic morphologically selected sperm injection (IMSI) in cases of macrocephalic sperm head syndrome. Design: Case report. Setting: Obstetrics, gynecology, urology, and reproductive biology departments. Patient(s): Two infertile patients with large-headed spermatozoa. Intervention(s): Fluorescence in situ hybridization on selected spermatozoa with normal-sized heads after IMSI selection. Main Outcome Measure(s): Percentages of polyploid, diploid, haploid aneuploid, and normal spermatozoa. Result(s): Of the six spermatozoa that could be selected, all were haploid but aneuploid. Conclusion(s): Absence of normal haploid spermatozoa among high magnification-selected spermatozoa contraindicated IMSI for these two patients. (Fertil Steril (R) 2010;93:1347.e1-e5. (C) 2010 by American Society for Reproductive Medicine.)