Longitudinal assessment of antimullerian hormone during pregnancy-relationship with maternal adiposity, insulin, and adiponectin

We examined in a prospective longitudinal pregnancy cohort the influence of advancing gestation and baseline maternal adiposity on antimullerian hormone (AMH) and determined whether maternal hormones (insulin, leptin, adiponectin, E(2), and sex hormone-binding globulin) correlate with alterations in AMH. We demonstrate that first-trimester AMH is associated negatively with maternal adiposity. that circulating levels decline during the second and third trimesters of pregnancy, and that in univariate and multivariate models adiponectin is associated positively with AMH during this period of pregnancy-related decline. (Fertil Steril (R) 2010;93:1356-8. (C) 2010 by American Society for Reproductive Medicine.)