Fertility preservation by ovarian stimulation and oocyte cryopreservation in a 14-year-old adolescent with Turner syndrome mosaicism and impending premature ovarian failure

Objective: To report a novel approach to fertility preservation in adolescents with Turner syndrome mosaicism by repeated controlled ovarian stimulation and oocyte cryopreservation. Design: Case report. Setting: Academic reproductive medicine center. Patient(s): Fourteen-year-old adolescent diagnosed with Turner syndrome mosaicism. Intervention(s): Two cyles of controlled ovarian stimulation and oocyte cryopreservation within 1 year. Main Outcome Measure(s): Recovery of oocytes after controlled ovarian stimulation and oocyte cryopreservation. Result(s): Eleven oocytes were retrieved, of which eight were mature and three were immature during the first cycle. One year later, four mature and three immature oocytes were retrieved after a treatment cycle with even higher gonadotropin doses. All oocytes were cryopreserved by vitrification. Conclusion(s): Controlled ovarian stimulation and oocyte cryopreservation may be an option for fertility preservation in selected adolescents with Turner syndrome mosaicism and impending ovarian failure. (Fertil Steril (R) 2010;94:753.e15-e19. (C) 2010 by American Society for Reproductive Medicine.)