期刊
FERTILITY AND STERILITY
卷 94, 期 7, 页码 2838-2842出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2010.04.052
关键词
Endometriosis; endometriotic cells; histone acetylation; histone deacetylase inhibitor; activity; apoptosis; proliferation; romidepsin
Romidepsin inhibited HDAC activity, produced acetylation of the histone proteins, up-regulated p21, and down-regulated cyclins B1 and D1, resulting in proliferation inhibition and apoptosis activation in 11z immortalized epithelial endometriotic cells. Our findings provide evidence that endometriotic cells are sensitive to the epigenetic effects of romidepsin and suggest that endometriosis may be therapeutically targeted by romidepsin. (Fertil Steril (R) 2010;94:2838-42. (C) 2010 by American Society for Reproductive Medicine.)
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据