期刊
FERTILITY AND STERILITY
卷 92, 期 5, 页码 1794-1798出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2009.05.004
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Immunohistochemical staining using human normal ovaries showed that bone morphogenetic protein-6 (BMP-6) was abundantly present in the granulosa cells (GC) of healthy tertiary follicles but not in atretic follicles. An in vitro study showed that BMP-6 induced gene expression of FSH receptor, inhibin/activin beta subunits, and anti-Mullerian hormone (AMH) in human GCs, suggesting that BMP-6 is an important mediator to support healthy follicle growth in the human ovary. (Fertil Steril (R) 2009;92:1794-8. (C)2009 by American Society for Reproductive Medicine.)
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