期刊
FERTILITY AND STERILITY
卷 90, 期 3, 页码 619-626出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2007.07.1292
关键词
obesity; sex hormones; sperm concentration; epidemiology
Objective: To evaluate whether overweight and obesity are related to changes in serum sex hormone concentrations and semen quality. Design: Cross-sectional study. Setting: Data from five previous population-based environmental studies of semen quality were combined into one database at a university hospital in Denmark. Patient(s): In total, 2,139 men provided data to the database. Intervention(s): Data on semen and blood samples and information on lifestyle and reproductive factors, including body mass index (BMI), were collected. Main Outcome Measure(s): Semen quality (volume, concentration, total sperm count, and motility) and serum concentration of sex hormones. Result(S): The T and inhibin B serum concentrations were 25%-32% lower in obese men in comparison with normal-weight men, whereas the E, concentration was 6% higher in obese men. Overweight men (BMI, 25.1-30.0 kg/m(2)) had a slightly lower adjusted sperm concentration and total sperm count than did men with a normal BMI (20.0-25.0 kg/m(2)), but no reduction in sperm count was observed among the obese men. Conclusion(s): These results corroborate earlier findings that overweight and obese men have a markedly changed sex hormone profile in serum, whereas reduction of semen quality, if any, was marginal and below the detection limit of this large study.
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