期刊
FERTILITY AND STERILITY
卷 90, 期 5, 页码 1692-1700出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2007.09.024
关键词
Human MII oocyte; oocyte morphology; pronuclear scoring; embryo scoring; implantation potential
Objective: To evaluate the influence of specific oocyte morphologic features (morphotypes) on intracytoplasmic sperm injection (ICSI) outcome. The identification of oocyte quality markers is particularly important when a low number of oocytes can be used for IVF. Design: Retrospective analysis. Setting: Medical center. Patient(s): Five hundred sixteen consecutive ICSI cycles. Only couples affected by severe male factor infertility were excluded. Intervention(s): A total of 1, 191. metaphase II (MII) oocytes (1-3 per patient) were randomly selected from the cohort of oocytes obtained from each patient and evaluated for morphologic appearance. Main Outcome Measure(s): Fertilization, pronuclear morphology, embryo quality, pregnancy rate. Result(s): There was a presence of vacuoles, abnormal I polar body, and large perivitelline space related to a lower fertilization rate. Pronuclear morphology was effected by the presence of a large perivitelline space, diffused cytoplasmic granularity, and/or centrally located granular area. The latter characteristic also negatively related to day 2 embryo quality. According to the odds ratios obtained for each oocyte morphotype to reach at least one outcome, an MII oocyte morphologic score (MOMS) was calculated. A significant relationship was found between MOMS and female age, female basal FSH, and clinical outcome. Conclusion(s): Morphologic evaluation before ICSI helps to identify MII oocytes with higher developmental potential. (Fertil Steril(R) 2008;90:1692-700. (C)2008 by American Society for Reproductive Medicine.)
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