期刊
FERTILITY AND STERILITY
卷 90, 期 -, 页码 1523-1527出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2007.09.001
关键词
photodynamic therapy; adenomyosis; 5-aminoleuvulinic acid
Objective: To evaluate the effect of photodynamic therapy with aminolevulinic acid (ALA) on human adenomyosis xenografts in a mouse model. Design: Human adenomyosis tissues were implanted SC into nude mice. We measured 5-aminolevulinic acid pharmacokinetics in these mice by analyzing tissue sections I to 6 hours after intraperitoneal administration. Twenty-four hours after photodynamic therapy, we evaluated tissue morphologic features. Setting: Department of obstetrics and gynecology at a university hospital in Japan. Patient(s): Immunodeficient mice. Tissue grafts were taken from women with adenomyosis attending a university hospital. Intervention(s): Photodynamic treatment. Main Outcome Measure(s): Peak fluorescence after intraperitoneal ALA administration and tissue histological changes 24 hours after photodynamic therapy. Result(s): Peak fluorescence was observed 3 hours after intraperitoneal administration. Histological studies revealed decreased numbers of epithelial and stromal cells in adenomyosis models after therapy. Conclusion(s): Photodynamic therapy with ALA caused extensive cell death in human adenomyosis tissues implanted into nude mice. Photodynamic treatment using ALA is a potential treatment for patients with adenomyosis uteri. (Fertil Steril (R) 2008;90:1523-7. (C)2008 by American Society for Reproductive Medicine.).
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