期刊
FEMS YEAST RESEARCH
卷 14, 期 7, 页码 1055-1067出版社
OXFORD UNIV PRESS
DOI: 10.1111/1567-1364.12196
关键词
glutathione homeostasis; GSH; GSSG; peroxisome; Grx1-roGFP2
资金
- Wellcome Trust Senior Research Fellowship
- ERC StG [260395]
- DFG [SFB 1036, SPP 1710]
- Visiting Scientist Fellowship from the German Cancer Research Center
- European Research Council (ERC) [260395] Funding Source: European Research Council (ERC)
Glutathione, the most abundant small-molecule thiol in eukaryotic cells, is synthesized de novo solely in the cytosol and must subsequently be transported to other cellular compartments. The mechanisms of glutathione transport into and out of organelles remain largely unclear. We show that budding yeast Opt2, a close homolog of the plasma membrane glutathione transporter Opt1, localizes to peroxisomes. We demonstrate that deletion of OPT2 leads to major defects in maintaining peroxisomal, mitochondrial, and cytosolic glutathione redox homeostasis. Furthermore, opt2 strains display synthetic lethality with deletions of genes central to iron homeostasis that require mitochondrial glutathione redox homeostasis. Our results shed new light on the importance of peroxisomes in cellular glutathione homeostasis.
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