期刊
FEMS MICROBIOLOGY LETTERS
卷 342, 期 2, 页码 79-88出版社
OXFORD UNIV PRESS
DOI: 10.1111/1574-6968.12128
关键词
antibiotic; differentiation; programmed cell death; secondary metabolism; sporulation; Streptomyces
类别
资金
- ERC [Strp-differentiation 280304]
- Subdireccion General de Proyectos de Investigacion, (DGI), Ministry of Science and Innovation (MICINN) [BIO2010-16303]
Streptomycetes comprise very important industrial bacteria, producing two-thirds of all clinically relevant secondary metabolites. They are mycelial microorganisms with complex developmental cycles that include programmed cell death (PCD) and sporulation. Industrial fermentations are usually performed in liquid cultures (large bioreactors), conditions in which Streptomyces strains generally do not sporulate, and it was traditionally assumed that there was no differentiation. In this work, we review the current knowledge on Streptomyces pre-sporulation stages of Streptomyces differentiation.
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