期刊
FEMS MICROBIOLOGY LETTERS
卷 332, 期 1, 页码 1-9出版社
OXFORD UNIV PRESS
DOI: 10.1111/j.1574-6968.2012.02566.x
关键词
intracelluar infection; drug delivery; nanoparticle
类别
Intracellular pathogens like Salmonella evade host phagocytic killing by various mechanisms. Classical antimicrobial therapy requires multiple dosages and frequent administration of drugs for a long duration. Intracellular delivery of antimicrobials using nanoparticle may effectively devise therapies for bacterial infections. This review will address the mechanisms used by Salmonella to avoid host pathogenic killing, reasons for therapeutic failure and advances in nanoparticle drug delivery technology for efficient intracellular bacterial clearance.
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