期刊
FEMS MICROBIOLOGY LETTERS
卷 326, 期 1, 页码 2-11出版社
OXFORD UNIV PRESS
DOI: 10.1111/j.1574-6968.2011.02406.x
关键词
Cpx envelope stress response; Escherichia coli; two-component signal transduction
类别
资金
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council (NSERC)
- Alberta Ingenuity
- Alberta Heritage Foundation for Medical Research
To detect and effectively respond to damage to the cell envelope, Gram-negative bacteria possess multiple envelope stress responses. Among these, the CpxAR two-component system has been shown to sense the presence of misfolded periplasmic proteins and increase the production of envelope-localized protein folding and degrading factors in response. However, recent studies have revealed that additional parameters, such as adhesion and central metabolism, can also be sensed by the Cpx signalling system. The discovery that the Cpx regulon contains dozens to hundreds of genes indicates that the cellular functions of the Cpx response are also likely much broader than previously realized. These newly recognized functions include other aspects of envelope maintenance, communication with other regulatory pathways, and pathogenesis. A new model is emerging in which the Cpx response integrates diverse signals and promotes cell survival by protecting the envelope in multiple ways.
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