期刊
FEMS MICROBIOLOGY LETTERS
卷 317, 期 2, 页码 109-116出版社
OXFORD UNIV PRESS
DOI: 10.1111/j.1574-6968.2011.02215.x
关键词
ciprofloxacin; gyrA; rifampicin; rpoB; Pseudomonas aeruginosa
类别
资金
- Uehara memorial foundation
- Ministry of Education, Science, Sports and Culture of Japan [21390191]
- Grants-in-Aid for Scientific Research [21390191, 21580250] Funding Source: KAKEN
The emergence of drug-resistant microorganisms is an important medical and social problem. Drug-resistant microorganisms are thought to grow selectively in the presence of antibiotics. Most clinically isolated drug-resistant microorganisms have mutations in the target genes for the drugs. While any of the many mutagens in the environment may cause such genetic mutations, no reports have yet described whether these mutagens can confer drug resistance to clinically important microorganisms. We investigated how environmental mutagens might be implicated in acquired resistance to antibiotics in clinically important microorganisms, which causes human diseases. We selected mutagens found in the environment, in cigarette smoke, or in drugs, and then exposed Pseudomonas aeruginosa to them. After exposure, the incidence of rifampicin- and ciprofloxacin-resistant P. aeruginosa strains markedly increased, and we found mutations in genes for the antibiotic-target molecule. These mutations were similar to those found in drug-resistant microorganisms isolated from clinical samples. Our findings show that environmental mutagens, and an anticancer drug, are capable of inducing drug-resistant P. aeruginosa similar to strains found in clinical settings.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据