期刊
FEMS MICROBIOLOGY LETTERS
卷 303, 期 1, 页码 61-68出版社
OXFORD UNIV PRESS
DOI: 10.1111/j.1574-6968.2009.01864.x
关键词
Scl1; cellular fibronectin; laminin; GAS internalization
类别
资金
- National Institutes of Health [AI50666]
- West Virginia University Health Science Center
- Office of Research and Graduate Education
- West Virginia Graduate Student Fellowships in Science
- Technology, Engineering and Mathematics program
The streptococcal collagen-like protein-1, Scl1, is widely expressed by the well-recognized human pathogen group A Streptococcus (GAS). Screening of human ligands for binding to recombinant Scl1 identified cellular fibronectin and laminin as binding partners. Both ligands interacted with the globular domain of Scl1, which is also able to bind the low-density lipoprotein. Native Scl1 mediated GAS adherence to ligand-coated glass cover slips and promoted GAS internalization into HEp-2 cells. This work identifies new ligands of the Scl1 protein that are known to be important in GAS pathogenesis and suggests a novel ligand-switching mechanism between blood and tissue environments, thereby facilitating host colonization and GAS dissemination.
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