期刊
FEMS MICROBIOLOGY LETTERS
卷 314, 期 1, 页码 10-17出版社
OXFORD UNIV PRESS
DOI: 10.1111/j.1574-6968.2010.02154.x
关键词
pathogenesis; secondary metabolite; small-molecule signaling; cell-cell communication; intercellular signal; antimicrobial therapies
类别
Microorganisms often use small chemicals or secondary metabolites as informational cues to regulate gene expression. It is hypothesized that microorganisms exploit these signals to gain a competitive advantage. Here, we present examples of pathogens that use this strategy to exclude other microorganisms from the site of infection. An emerging theme is that inhibiting these systems presents a novel approach to antimicrobial therapies.
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