期刊
FEMS MICROBIOLOGY LETTERS
卷 307, 期 2, 页码 135-141出版社
OXFORD UNIV PRESS
DOI: 10.1111/j.1574-6968.2010.01973.x
关键词
Staphylococcus aureus; licochalcone A; subinhibitory concentrations; enterotoxins
类别
资金
- 973 programme of China [2006CB504402]
Enterotoxins produced by Staphylococcus aureus are the key pathogenicity factors that can cause a variety of illnesses in humans, including staphylococcal gastroenteritis and food poisoning. It has been proven that licochalcone A is a potentially effective antimicrobial agent against S. aureus. In this study, Western blot assays, tumour necrosis factor release assays, murine T-cell proliferation assays, and real-time reverse transcriptase-PCR were performed to evaluate the effect of subinhibitory concentrations of licochalcone A on the secretion of two major enterotoxins (SEA and SEB) by S. aureus. The results show that licochalcone A significantly decreased, in a dose-dependent manner, the secretion of SEA and SEB by both methicillin-sensitive S. aureus and methicillin-resistant S. aureus. These results may increase the desirability of using licochalcone A as a lead compound for the design of more potent antibacterial agents based on the chalcone template.
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