期刊
FEMS MICROBIOLOGY LETTERS
卷 290, 期 1, 页码 85-90出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1574-6968.2008.01409.x
关键词
bubonic plague; two-component systems; Caenorhabditis elegans
类别
资金
- U.S. Public Health Service [AI057512]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI057512, R56AI057512] Funding Source: NIH RePORTER
A few Yersinia pseudotuberculosis strains form biofilms on the head of the nematode Caenorhabditis elegans, but numerous others do not. We show that a widely used Y. pseudotuberculosis strain, YPIII, is biofilm positive because of a mutation in phoP, which encodes the response regulator of a two-component system. For two wild-type Y. pseudotuberculosis that do not make biofilms on C. elegans, deletion of phoP was sufficient to produce robust biofilms. In Yersinia pestis, a phoP mutant made more extensive biofilms in vitro than did the wild type. Expression of HmsT, a diguanylate cyclase that positively regulates biofilms, is diminished in Y. pseudotuberculosis strains with functional PhoP.
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