期刊
FEMS MICROBIOLOGY LETTERS
卷 297, 期 2, 页码 261-265出版社
OXFORD UNIV PRESS
DOI: 10.1111/j.1574-6968.2009.01690.x
关键词
folate biosynthesis genes; folate overproduction; Lactobacillus plantarum; methotrexate resistance; natural overproduction
类别
Folate overproduction can serve as a mode of resistance against the folate antagonist methotrexate in Lactobacillus plantarum WCFS1. When compared with a wild-type control strain, an engineered high folate-producing strain was found to be insensitive to methotrexate. The growth rate and the viable count of the folate-overproducing L. plantarum strain were not significantly affected by the presence of methotrexate in the growth medium.
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