期刊
FEMS MICROBIOLOGY LETTERS
卷 291, 期 2, 页码 157-161出版社
OXFORD UNIV PRESS
DOI: 10.1111/j.1574-6968.2008.01451.x
关键词
acetic acid bacteria; respiratory chain; NADH dehydrogenase; inhibitor; antibiotics
类别
资金
- Japanese Ministry of Education, Science, Culture, Sports, and Technology [20570124, 18073004, 18GS0314]
- Grants-in-Aid for Scientific Research [18073004, 20570124] Funding Source: KAKEN
In bacterial membranes and plant, fungus and protist mitochondria, NADH dehydrogenase (NDH-II) serves as an alternative NADH : quinone reductase, a non-proton-pumping single-subunit enzyme bound to the membrane surface. Because NDH-II is absent in mammalian mitochondria, it is a promising target for new antibiotics. However, inhibitors for NDH-II are rare and unspecific. Taking advantage of the simple organization of the respiratory chain in Gluconobacter oxydans, we carried out screening of natural compounds and identified scopafungin and gramicidin S as inhibitors for G. oxydans NDH-II. Further, we examined their effects on Mycobacterium smegmatis and Plasmodium yoelii NDH-II as model pathogen enzymes.
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