期刊
FEMS MICROBIOLOGY LETTERS
卷 287, 期 2, 页码 185-191出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1574-6968.2008.01308.x
关键词
lysostaphin; turbidity assay; minimal inhibitory concentration; LytM; ALE-1; LAS
类别
LysK is the endolysin from the staphylococcal bacteriophage K, and can digest the cell wall of many staphylococci. Lysostaphin is a bacteriocin secreted by Staphylococcus simulans to kill Staphylococcus aureus. Both LysK and lysostaphin have been shown to lyse methicillin-resistant S. aureus (MRSA). This study describes optimal reaction conditions for the recombinant His-tagged LysK protein (pH range pH 6-10, and 0.3-0.5 M NaCl), and C-His-LysK MIC (32.85 +/- 4.87 mu g mL(-1)). LysK and lysostaphin demonstrate antimicrobial synergy by the checkerboard assay.
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